Dr. Kevin P. C. Minbiole
Organic + Natural Products Chemistry
Professor of Chemistry
Director, Chemistry MS Program
office: 300A Mendel Hall
updated January 2018
We have an NSF grant
in collaboration with Drs. Louise Rollins-Smith (Vanderbilt) and Tom
Umile (Gwynedd-Mercy) to investigate Bd metabolites! Check out our blog, Frogs in Peril.
We have another NSF grant, working with Dr. Tanya Livshultz at Drexel/the Academy of Natural Sciences and Dr. Shannon Straub at Hobart and William Smith College.
2018 has started well, KPCM's 50th paper just accepted.
Congrats to Julia, the first author!!
Click here for a recent group picture.
Nature provides us with a tremendous variety of small molecules that
possess fascinating structure and potent medicinal properties. Their
biological origin is as diverse as their chemical composition (see
below). One half of the research group is working to identify bioactive
natural products that are associated with amphibian defense. We
also working to prepare novel antibacterial/antiseptic compounds to
combat antibiotic-resistant bacterial infections.
Natural Product Isolation Projects: Globally, amphibians
face one of the largest extinction rates in the animal kingdom. Although
habitat destruction is a major cause of amphibian extinctions, infection
from the fungal pathogen, Batrachochytrium dendrobatidis, is a
large contributor. Our group is working in collaboration with multiple ecologists, including Dr. Doug Woodhams at UMass-Boston, to examine bacterially-produced natural
products endemic to the skins of frogs, salamanders, and toads that may confer
protection against this chytrid fungus. We also collaborate with
Dr. Louise Rollins-Smith at Vanderbilt University and Dr. Tom Umile at Gwynedd-Mercy University, to further
and its natural products. We recently have begun working with
Drs. Tanya Livshultz and Dr. Shannon Straub to look into plant
Panamanian Golden Frog, photo by B. Gratwicke
Three of the compounds we've isolated from bacteria on salamander
Medicinal Chemistry Project: Bacteria are developing
resistance at a rate faster than new antibiotics are coming to
are developing novel polycationic antiseptics to more efficiently disrupt cell
membranes and lyse bacteria. Working with Dr. Bill Wuest
at Emory University, we are exploring how our compounds disrupt
biofilms. Since 2014, we have collaborated a dozen or so publications (list),
as we learn what cationic amphiphile structures are most effective at
inhibiting bacterial growth, including biofilms. This has led to a spinoff company, NovaLyse Biosolutions.