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KPCM

Dr. Kevin P. C. Minbiole
Organic + Natural Products Chemistry
 
Professor of Chemistry
Director, Chemistry MS Program
office:  300A Mendel Hall
email: kevin.minbiole@villanova.edu 
voice:  610-519-4873

GROUP NEWS
updated March 2018

We have an NSF grant in collaboration with Drs. Louise Rollins-Smith (Vanderbilt) and Tom Umile (Gwynedd-Mercy) to investigate Bd metabolites!  Check out our blog, Frogs in Peril

We have another NSF grant, working with Dr. Tanya Livshultz at Drexel/the Academy of Natural Sciences and Dr. Shannon Straub at Hobart and William Smith College.

2018 has started well, KPCM's 50th paper just accepted.
Congrats to Julia, the first author!!

Click here for a recent group picture.

Click here for a picture of the group at the New Orleans ACS Meeting in March 2018!

 

Research Interests: Nature provides us with a tremendous variety of small molecules that possess fascinating structure and potent medicinal properties. Their biological origin is as diverse as their chemical composition (see below). One half of the research group is working to identify bioactive natural products that are associated with amphibian defense.  We also working to prepare novel antibacterial/antiseptic compounds to combat antibiotic-resistant bacterial infections.  


 
Natural Product Isolation Projects:  Globally, amphibians face one of the largest extinction rates in the animal kingdom. Although habitat destruction is a major cause of amphibian extinctions, infection from the fungal pathogen, Batrachochytrium dendrobatidis, is a large contributor.  Our group is working in collaboration with multiple ecologists, including Dr. Doug Woodhams at UMass-Boston, to examine bacterially-produced natural products endemic to the skins of frogs, salamanders, and toads that may confer protection against this chytrid fungus.  We also collaborate with Dr. Louise Rollins-Smith at Vanderbilt University and Dr. Tom Umile at Gwynedd-Mercy University, to further investigate Bd and its natural products.  We recently have begun working with Drs. Tanya Livshultz and Dr. Shannon Straub to look into plant alkaloids.
Panamanian Golden Frog, photo by B. Gratwicke

         
                Three of the compounds we've isolated from bacteria on salamander skin.                                          
                                                                                              
Medicinal Chemistry Project:  Bacteria are developing resistance at a rate faster than new antibiotics are coming to market.  We are developing novel polycationic antiseptics to more efficiently disrupt cell membranes and lyse bacteria.  Working with Dr. Bill Wuest at Emory University, we are exploring how our compounds disrupt biofilms. Since 2014, we have collaborated on nearly 20 publications (list), as we learn what cationic amphiphile structures are most effective at inhibiting bacterial growth, including biofilms.

 

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