Dr. Kevin P. C. Minbiole

Experience
Assistant Professor, Villanova University, 2011 to present

Adjunct Professor, James Madison University,  2011 to present

Associate Professor, James Madison University, 2009 to 2011

Assistant Professor, James Madison University, 2003 to 2009

Visiting Professor, Massachusetts Institute of Technology, Fall 2006

Education
B.S., University of Notre Dame, 1996
Advisor: Professor Paul Helquist

Ph.D., University of Pennsylvania, 2001
Advisor: Professor Amos B. Smith, III.  (photo)
Thesis: The Total Synthesis of Phorboxazole A

Postdoctoral Research, Harvard University, 2001-2003
Advisor: Professor Andrew Myers
American Cancer Society Fellow

Publications (Undergraduate coworkers underlined).
17.  Molly Bletz; Andrew Loudon; Matthew Becker; Sara Bell; Douglas Woodhams; Kevin Minbiole; Reid Harris.  Mitigating amphibian chytridiomycosis with bioaugmentation: Characteristics of effective probiotics and strategies for their selection and use.  Ecology Letters. 2013, in press.

16.  Jeremy P. Ramsey, Albert Mercurio, Jessica A. Holland, Reid N. Harris, Kevin P.C. Minbiole.  The Cutaneous Bacterium Janthinobacterium lividum Inhibits the Growth of Trichophyton rubrum In Vitro.  International Journal of Dermatology, 2013, in press.

15.  Jillian M. Myers, Jeremy P. Ramsey, Alison L. Blackman, A. Elizabeth Nichols, Kevin P. C. Minbiole, And Reid N. Harris.  Synergistic Inhibition Of The Lethal Fungal Pathogen Batrachochytrium Dendrobatidis: The Combined Effect Of Symbiotic Bacterial Metabolites And Antimicrobial Peptides Of The Frog Rana Muscosa.  The Journal of Chemical Ecology.  2012, 958-965.  Link.

14.  Melissa C. Grenier, Robert W. Davis, Kelsey L. Wilson-Henjum, Jade E. LaDow, Jacob W. Black, Kevin L. Caran, Kyle Seifert, Kevin P. C. Minbiole.  The Antibacterial Activity of 4,4’-Bipyridinium Amphiphiles with Conventional, Bicephalic and Gemini Architectures. Bioorganic and Medicinal Chemistry Letters, 2012, 4055-4058. Link.

13.  Matthew H. Becker, Reid N. Harris, Kevin P. C. Minbiole, Christian R. Schwantes, Louise A. Rollins-Smith, Laura K. Reinert, Robert M. Brucker, Rickie J. Domangue, Brian Gratwicke. Towards a better understanding of the use of probiotics for preventing chytridiomycosis in Panamanian golden frogs.  EcoHealth, 2011, 501-506. Link

12.  Jade E. LaDow, David C. Warnock, Kristina M. Hamill, Kaitlin L. Simmons, Robert W. Davis, Christian R. Schwantes, Devon C. Flaherty, Kevin L. Caran,  Kevin P. C. Minbiole, and Kyle Seifert. Bicephalic Amphiphile Architecture Affects Antimicrobial Activity.  European Journal of Medicinal Chemistry, 2011, 4219-4226. Link

11.  Kevin P. C. Minbiole, Patrick J. Wiggins, Jacob Smith, Reid N. Harris. The Salamander Gut May Serve as a Reservoir for an Antifungal Cutaneous Bacterium.  Journal of Herpetology, 2011, 329-332.  Link.

10. Matthew Becker, Robert Brucker, Reid N. Harris, Christian Schwantes, Kevin P. C. Minbiole. The bacterially-produced metabolite violacein is associated with survival in amphibians infected with a lethal disease. Applied and Environmental Microbiology, 2009, 75, 21, 6635-6638. 

9. Reid N. Harris, Robert M. Brucker, Jenifer B. Walke, Matthew H. Becker, Christian R. Schwantes, Devon C. Flaherty, Brianna A. Lam, Doug C. Woodhams, Cheryl J. Briggs, Vance T. Vredenburg, Kevin P. C. Minbiole. Skin microbes on frogs prevent morbidity and mortality caused by a lethal skin fungus,  ISME Journal,  2009, 3, 818-824. 

8. Robert M. Brucker, Reid N. Harris, Christian R. Schwantes, Thomas N. Gallaher, Devon C. Flaherty, Brianna A. Lam, Kevin P. C. Minbiole. Amphibian chemical defense: Antifungal metabolites of the microsymbiont Janthinobacterium lividum on the salamander Plethodon cinereus. J. Chem. Ecol. 2008, 34, 1422-1429.

7. Robert M. Brucker, Cambria M. Baylor, Robert L. Walters, Antje Lauer, Reid N. Harris, Kevin P. C. Minbiole. The Identification of 2,4-diacetylphloroglucinol as an Antifungal Metabolite Produced by Cutaneous Bacteria of the Salamander Plethodon cinereus.  J. Chem. Ecol. 2008, 34, 39-43.

6. Kerry E. O'Neil, Seth V. Kingree, Kevin P. C. Minbiole.  A Cyclopropane Fragmentation Approach to Heterocycle Assembly:  A Convergent Synthesis of Oxepanes.  Org. Lett., 2005, 7, 515-517.  

5. Amos B. Smith, III; Kevin P. Minbiole; Patrick R. Verhoest; Michael Schelhaas. Total Synthesis of (+)-Phorboxazole A Exploiting the Petasis-Ferrier Rearrangement. J. Am. Chem. Soc. 2001, 123, 10942-10953.

4. Amos B. Smith, III; Kevin P. Minbiole; Scott Freeze. Facile Assembly of 2,4-Orthogonally-Functionalized Oxazoles: Useful Bidirectional Linchpins. Synlett 2001, 13, 1739-1742.

3. Amos B. Smith, III; Patrick R. Verhoest; Kevin P. Minbiole; Michael Schelhaas. Total Synthesis of (+)-Phorboxazole A. J. Am. Chem. Soc. 2001, 123, 4834-4836.

2. Amos B. Smith, III; Kevin P. Minbiole; Patrick R. Verhoest; Thomas J. Beauchamp. Phorboxazole Synthetic Studies. 2. Construction of a C(20-28) Subtarget, a Further Extension of the Petasis-Ferrier Rearrangement. Org. Lett. 1999, 1, 913-916.

1. Amos B. Smith, III; Patrick R. Verhoest; Kevin P. Minbiole; John J. Lim. Phorboxazole Synthetic Studies. 1. Construction of a C(3-19) Subtarget Exploiting an Extension of the Petasis-Ferrier Rearrangement. Org. Lett. 1999, 1, 909-912.
 

Book Chapter
Minbiole, K. P. C. “Product Class 46.4: 1,3 Dienes; Synthesis by Aldol and Related Condensations.” In Science of Synthesis; Volume 46; Rawal, V. H. and Kozmin, S. A., Volume Editors. Georg Thieme Verlag: Stuttgart, September 2009.

Mini-review
Harris, R. N.; Minbiole, K. P. C.  "Can Manipulations of Amphibians’ Mutualistic Skin Bacteria Control a Lethal Skin Disease?"  Biocontrol News and Information 2009, 30 (2), 19N–20N. (PDF)

Patents
US Provisional Application; "Antimicrobial Amphiphiles and Methods for their Use."  Submitted October 2011

US Patent Application 12/829,520 and International Patent Application US10/40898;  "Probiotic Compositions and Processes Thereof."  July 2010